An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery

@inproceedings{Kalson2010AnEM,
  title={An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery},
  author={Nicholas S Kalson and David F. Holmes and Z A Kapacee and Iker Otermin and Yinhui Lu and Roland A. Ennos and Elizabeth Gail Canty-Laird and Karl E Kadler},
  booktitle={Matrix biology : journal of the International Society for Matrix Biology},
  year={2010}
}
Tendons attach muscles to bone and thereby transmit tensile forces during joint movement. However, a detailed understanding of the mechanisms that establish the mechanical properties of tendon has remained elusive because of the practical difficulties of studying tissue mechanics in vivo. Here we have performed a study of tendon-like constructs made by culturing embryonic tendon cells in fixed-length fibrin gels. The constructs display mechanical properties (toe-linear-fail stress-strain curve… CONTINUE READING

From This Paper

Figures and tables from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Fell Muir Lecture: Collagen fibril formation in vitro and in vivo.

International journal of experimental pathology • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Engineering of functional tendon.

Tissue engineering • 2004
View 4 Excerpts
Highly Influenced

Quantitative analysis of gene expression in human articular cartilage from normal and osteoarthritic joints

I. Martin, M. Jakob, +3 authors M. Heberer
Osteoarthritis Cartilage • 2001
View 3 Excerpts
Highly Influenced

Whole cell mechanics of contractile fibroblasts: relations between effective cellular and extracellular matrix moduli.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences • 2010
View 2 Excerpts

Evidence against proteoglycan mediated collagen fibril load transmission and dynamic viscoelasticity in tendon.

Matrix biology : journal of the International Society for Matrix Biology • 2009
View 2 Excerpts

Similar Papers

Loading similar papers…