An expedient route to 2,3-substituted and fused benzo[a]quinolizine-4-thione framework via ring annulation with beta-oxodithioesters.


[figure: see text] An efficient highly convergent route to hitherto unreported 2,3-substituted and annulated benzo[a]quinolizine-4-thiones 3 has been developed. The methodology involves ring annulation of 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline 1 with a variety of readily accessible acyclic and cyclic beta-oxodithioesters 2 in the presence of… (More)


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