An expectation maximization approach to estimate malaria haplotype frequencies in multiply infected children.

@article{Li2007AnEM,
  title={An expectation maximization approach to estimate malaria haplotype frequencies in multiply infected children.},
  author={Xiaohong Li and Andrea S. Foulkes and Recai M. Yucel and Stephen M. Rich},
  journal={Statistical applications in genetics and molecular biology},
  year={2007},
  volume={6},
  pages={Article33}
}
Characterizing genetic variability in the human pathogenic Plasmodium species, the group of parasites that cause Malaria, may have broad global health implications. Specifically, discerning the combinations of mutations that lead to viable parasites and the population level frequencies of these clonal sequences will allow for targeted vaccine development and individualized treatment choices. This presents an analytical challenge, however, since haplotypic phase (i.e. the alignment of bases on a… CONTINUE READING
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