An exercise-inducible metabolite that suppresses feeding and obesity.

  title={An exercise-inducible metabolite that suppresses feeding and obesity.},
  author={Veronica L. Li and Yang He and K{\'e}vin Contrepois and Hailan Liu and Joon T Kim and Amanda L Wiggenhorn and Julia T. Tanzo and Alan Sheng-Hwa Tung and Xuchao Lyu and Peter-James H. Zushin and Robert S. Jansen and Basil Michael and Kang Yong Loh and Andrew C. Yang and Christian S. Carl and Christian T. Voldstedlund and Wei Wei and Stephanie M. Terrell and Benjamin C. Moeller and Rick M. Arthur and Gareth A. Wallis and Koen van de Wetering and Andreas Stahl and Bente Kiens and Erik A. Richter and Steven M. Banik and Michael P. Snyder and Yong Xu and Jonathan Z. Long},
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases1-5. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear6. Here we show that exercise stimulates the production of N-lactoyl-phenylalanine (Lac-Phe), a blood-borne signalling metabolite that suppresses feeding and obesity. The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages… 

Increased Levels of N-Lactoylphenylalanine After Exercise are Related to Adipose Tissue Loss During Endurance Training in Humans With Overweight and Obesity

Higher levels of Lac-Phe after acute exercise were associated with a greater reduction in abdominal adipose tissue during the intervention and could support weight loss in humans.

An exercise-induced metabolite alters feeding

There is an exercise inducible metabolite called Lac-Phe that is increased dramatically with exercise in mammals and acts to reduce food intake and thus also to decrease overall body weight and fat mass, according to a new paper in Nature.

Role of brain-gut-muscle axis in human health and energy homeostasis

The interaction of intestinal microbiota, central nervous, skeletal muscle energy metabolism, and feeding behavior regulation is focused on, which will provide new insight into the diagnostic and treatment strategies for obesity, diabetes, and other metabolic diseases.

Reply to ‘Lactate as a major myokine and exerkine’

Lactate has an integral role in the exercise response and a more fleshed-out description of its impact, and lactate’s meta bolic effects in driving exercise-induced adaptions are described.

Tryptophan metabolism is a physiological integrator regulating circadian rhythms

The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

The A1 haplotype may promote healthy insulin sensitivity in non-Hispanic whites and lactate likely play a role in this process but not selected gut bacteria, as well as potential mediating pathways.

Understanding emerging bioactive metabolites with putative roles in cancer biology

It is proposed that these metabolites could play a bioactive role in promoting or inhibiting cancer cell phenotypes in a manner that is mostly unexplored, either as post-translational modifications (PTMs) on proteins or in, yet unknown ways.

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

The findings indicated the mediating role of DII in the association between LPA condition and incident depression, and more well-designed studies are still needed to validate the causal relationship.

Interaction of microbiome and immunity in tumorigenesis and clinical treatment.

  • Yue YuWen-wei Zhong
  • Biology, Medicine
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2022



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