An excitatory scorpion toxin with a distinctive feature: an additional alpha helix at the C terminus and its implications for interaction with insect sodium channels.

@article{Oren1998AnES,
  title={An excitatory scorpion toxin with a distinctive feature: an additional alpha helix at the C terminus and its implications for interaction with insect sodium channels.},
  author={Deena A. Oren and Oren Froy and E Amit and N Kleinberger-Doron and Michael Gurevitz and Boaz Shaanan},
  journal={Structure},
  year={1998},
  volume={6 9},
  pages={1095-103}
}
BACKGROUND Scorpion neurotoxins, which bind and modulate sodium channels, have been divided into two groups, the alpha and beta toxins, according to their activities. The beta-toxin class includes the groups of excitatory and depressant toxins, which differ in their mode of action and are highly specific against insects. The three-dimensional structures of several alpha and beta toxins have been determined at high resolution, but no detailed 3D structure of an excitatory toxin has been… CONTINUE READING

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