An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia.

@article{StaszewkaBarczak1976AnEN,
  title={An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia.},
  author={J Staszewka-Barczak and S{\'e}rgio Henrique Ferreira and John R. Vane},
  journal={Cardiovascular research},
  year={1976},
  volume={10 3},
  pages={314-27}
}
Application of bradykinin to the exposed ventricular surface of the dog heart elicits a reflex cardiovascular response which includes a rise in blood pressure, tachycardia, renal vasoconstriction and muscular vasodilation. The reflex response depends on the dose of bradykinin and is increased by concomitant application of prostaglandin E1 or E2 and reduced by indomethacin. Temporary occlusion of the coronary artery supplying the area of the ventricle under study also sensitized the heart to… CONTINUE READING