An examination of the role of increased cytosolic free Ca2+ concentrations in the inhibition of mRNA translation.

@article{Laitusis1998AnEO,
  title={An examination of the role of increased cytosolic free Ca2+ concentrations in the inhibition of mRNA translation.},
  author={A L Laitusis and Charles O. Brostrom and Alexey G. Ryazanov and Margaret A. Brostrom},
  journal={Archives of biochemistry and biophysics},
  year={1998},
  volume={354 2},
  pages={270-80}
}
Mobilization of Ca2+ sequestered by the endoplasmic reticulum (ER) produces the phosphorylation of initiation factor (eIF) 2, whereas an increase in cytosolic free Ca2+ ([Ca2+]i) due to plasmalemmal Ca2+ influx increases the phosphorylation of elongation factor (eEF) 2. In nucleated mammalian cells, depletion of ER Ca2+ stores has been demonstrated to inhibit translational initiation, but evidence that increased [Ca2+]i per se causes slowing of peptide chain elongation is lacking. L-type Ca2… CONTINUE READING