An examination of beta-cell function measures and their potential use for estimating beta-cell mass.

@article{Kahn2008AnEO,
  title={An examination of beta-cell function measures and their potential use for estimating beta-cell mass.},
  author={Steven E Kahn and Darcy B. Carr and Mirjam V. Faulenbach and Kristina M. Utzschneider},
  journal={Diabetes, obesity & metabolism},
  year={2008},
  volume={10 Suppl 4},
  pages={63-76}
}
A characteristic and dominant feature of type 2 diabetes is a reduction in beta-cell function that is associated with a decrease in beta-cell volume. A decline in the first-phase insulin response following intravenous glucose administration can be demonstrated as the fasting glucose concentration increases. This response is completely absent before the glucose threshold that defines diabetes has been reached and at a time when beta-cells are clearly still present, implying that a functional… CONTINUE READING

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