An exactly solvable Ogston model of gel electrophoresis. VI. Towards a theory for macromolecules.

@article{Boileau2001AnES,
  title={An exactly solvable Ogston model of gel electrophoresis. VI. Towards a theory for macromolecules.},
  author={Justin Boileau and Gary W. Slater},
  journal={Electrophoresis},
  year={2001},
  volume={22 4},
  pages={673-83}
}
In this article, we present a generalized version of our lattice model of low-field gel electrophoresis that allows us to treat the case of macromolecules such as short linear or circular oligomers and semi-flexible rods. We show that free-solution electrophoresis problems can be seen as random walks in the conformational space of the analyte. For sufficiently small molecules, our mathematical approach provides exact mobilities. In a quenched gel-like environment, however, both conformational… CONTINUE READING

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