An exact test for the association between the disease and alleles at highly polymorphic loci with particular interest in the haplotype analysis.

@article{Hirotsu2001AnET,
  title={An exact test for the association between the disease and alleles at highly polymorphic loci with particular interest in the haplotype analysis.},
  author={Chihiro Hirotsu and S. Aoki and Toshiki Inada and Yoshie Kitao},
  journal={Biometrics},
  year={2001},
  volume={57 3},
  pages={769-78}
}
The association analysis between the disease and genetic alleles is one of the simple methods for localizing the susceptibility locus in the genes. For revealing the association, several statistical tests have been proposed without discussing explicitly the alternative hypotheses. We therefore specify two types of alternative hypotheses (i.e., there is only one susceptibility allele in the locus, and there is an extension or shortening of alleles associated with the disease) and derive exact… CONTINUE READING

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