An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization.

@article{Mazzalupo2002AnEV,
  title={An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization.},
  author={Stacy Mazzalupo and Matthew J Wawersik and Pierre A Coulombe},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={118 5},
  pages={866-70}
}
Wound closure following injury to the skin is a complex process involving both dermal contraction and keratinocyte migration. Murine models of wound healing are potentially useful because of the ability to determine protein function through gene manipulation. Owing to the dominant role of dermal contraction, the technical difficulties in preparing the wound site for morphologic studies, and the postnatal phenotypes altering the properties of transgenic skin, there are difficulties in assessing… CONTINUE READING

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