An evolutionary treasure: unification of a broad set of amidohydrolases related to urease

  title={An evolutionary treasure: unification of a broad set of amidohydrolases related to urease},
  author={Liisa Holm and Chris Sander},
  journal={Proteins: Structure},
The recent determination of the three‐dimensional structure of urease revealed striking similarities of enzyme architecture to adenosine deaminase and phosphotriesterase, evidence of a distant evolutionary relationship that had gone undetected by one‐dimensional sequence comparisons. Here, based on an analysis of conservation patterns in three dimensions, we report the discovery of the same active‐site architecture in an even larger set of enzymes involved primarily in nucleotide metabolism. As… 

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