An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects

@article{Eisenberg2011AnER,
  title={An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects},
  author={D. Eisenberg},
  journal={American Journal of Human Biology},
  year={2011},
  volume={23}
}
  • D. Eisenberg
  • Published 2011
  • Biology, Medicine
  • American Journal of Human Biology
Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role in regulating cellular proliferation, and shorten with increasing age in proliferating human tissues. The rate of age‐related shortening of telomeres is highest early in life and decreases with age. Shortened telomeres are thought to limit the proliferation of cells and are associated with increased morbidity and mortality. Although natural selection is widely assumed to operate against long telomeres… Expand
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References

SHOWING 1-10 OF 354 REFERENCES
Telomeres and Telomerase in the Fetal Origins of Cardiovascular Disease: A Review
TLDR
Evidence is summarized for one genetic mechanism, telomere attrition, that may underlie the fetal origins of cardiovascular disease and this mechanism is discussed in light of the evolution of senescence. Expand
Short telomeres in short-lived males: what are the molecular and evolutionary causes?
TLDR
It is found that somatic tissues of the short‐lived males had dramatically shorter telomeres than those of the much longer‐lived queens and workers, and various molecular mechanisms that are likely to cause the observed sex‐specific telomere dynamics in ants are discussed, including cell division, oxidative stress and telomerase activity. Expand
Telomeres and life histories: the long and the short of it
  • P. Monaghan
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2010
TLDR
What the authors do and do not know about the links between telomeres length and life histories and the extent to which variations in telomere length and loss rate are useful indicators of aging‐related changes and/or the biological state of individuals are discussed. Expand
Telomeres, cell senescence and human ageing
TLDR
How uncapped telomeres initiate a signalling cascade toward senescence, and why oxidative stress is a major cause of telomere shortening are reviewed are reviewed. Expand
Telomere length homeostasis
TLDR
This model is expanded to incorporate the finding that telomerase levels also limit telomere length and proposes a second switch between a non-telomerase-associated “extendible” and a telomerases-associated "extending” state, which suggests a model in which telomeres switch between extendible and nonextendible states in a length-dependent manner. Expand
Telomere biology in mammalian germ cells and during development.
TLDR
Recent advances in understanding of telomere biology in germline cells as well as during development (pre- and postimplantation periods) are focused on in an attempt to summarize knowledge about telomeres length determination and its importance for normal development in utero and the occurrence of the aging and abnormal phenotype later on. Expand
Cellular senescence, cancer and aging: the telomere connection
TLDR
What is known about mammalian telomeres and the proteins that associate with them are reviewed, and the cellular and organismal consequences of telomere dysfunction and the evidence that cells with dysfunctional telomeric structure can contribute to cancer and aging phenotypes are discussed. Expand
Telomeres, immune aging and autoimmunity
Telomere length is important in constraining the replicative potential of cells; cellular systems that are dependent on cell replenishment for renewal or on cell proliferation for functionality areExpand
Telomere loss in relation to age and early environment in long-lived birds
TLDR
Telomere dynamics in two long–lived seabirds, the European shag and the wandering albatross, are examined, finding high inter–individual variation in the magnitude of telomere loss, much of which was explained by circumstances during growth. Expand
Telomere shortening and ageing of the immune system.
  • L. Kaszubowska
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2008
TLDR
Lineage-specific telomere shortening with different kinetics of telomeres attrition was observed in CD4+, CD8+ T lymphocytes, B lymphocyte, granulocytes, monocytes and NK cell population. Expand
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