An evolutionary perspective on field cancerization

@article{Curtius2018AnEP,
  title={An evolutionary perspective on field cancerization},
  author={Kit Curtius and Nicholas Anthony Wright and Trevor A Graham},
  journal={Nature Reviews Cancer},
  year={2018},
  volume={18},
  pages={19-32}
}
Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed, even before any of the usual morphological correlates of pre-malignancy are recognizable. Field cancerization, which is the replacement of the normal cell population by a cancer-primed cell population that may show no morphological change, is now recognized to underlie the development of many types of cancer, including the common carcinomas of the lung, colon, skin, prostate and bladder. Field… CONTINUE READING
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