An evolutionary perspective on field cancerization
@article{Curtius2018AnEP, title={An evolutionary perspective on field cancerization}, author={K. Curtius and N. A. Wright and T. Graham}, journal={Nature Reviews Cancer}, year={2018}, volume={18}, pages={19-32} }
Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed, even before any of the usual morphological correlates of pre-malignancy are recognizable. Field cancerization, which is the replacement of the normal cell population by a cancer-primed cell population that may show no morphological change, is now recognized to underlie the development of many types of cancer, including the common carcinomas of the lung, colon, skin, prostate and bladder. Field… CONTINUE READING
Paper Mentions
Blog Post
129 Citations
Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.
- Biology, Medicine
- Trends in cancer
- 2019
- 7
Field Carcinogenesis in Cancer Evolution: What the Cell Is Going On?
- Biology, Medicine
- Cancer Research
- 2020
- Highly Influenced
Spread of premalignant mutant clones and cancer initiation in multilayered tissue
- Mathematics, Biology
- 2020
- PDF
From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology
- Biology, Medicine
- Front. Immunol.
- 2018
- 7
- PDF
Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis
- Medicine
- OncoTargets and therapy
- 2020
- 2
- PDF
Cooperation of partially-transformed clones: an invisible force behind the early stages of carcinogenesis
- Biology
- 2018
- PDF
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
- Biology, Medicine
- Nature Communications
- 2019
- 5
- PDF
The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics.
- Medicine
- Journal of thoracic disease
- 2019
Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship
- Biology, Medicine
- Scientific reports
- 2020
- PDF
References
SHOWING 1-10 OF 225 REFERENCES
Field cancerization in mammary carcinogenesis - Implications for prevention and treatment of breast cancer.
- Biology, Medicine
- Experimental and molecular pathology
- 2012
- 40
Field cancerization in non-small cell lung cancer: implications in disease pathogenesis.
- Biology, Medicine
- Proceedings of the American Thoracic Society
- 2012
- 58
Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets
- Biology, Medicine
- The Journal of pathology
- 1999
- 181
Enriching the Molecular Definition of the Airway “Field of Cancerization:” Establishing New Paradigms for the Patient at Risk for Lung Cancer
- Biology, Medicine
- Cancer Prevention Research
- 2012
- 21
- PDF
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2013
- 313
- PDF
Multifocality and recurrence risk: a quantitative model of field cancerization.
- Biology, Medicine
- Journal of theoretical biology
- 2014
- 24
- PDF
Cell migration leads to spatially distinct but clonally related airway cancer precursors
- Medicine
- Thorax
- 2014
- 26
- PDF
Clonal evolution of colorectal cancer in IBD
- Medicine
- Nature Reviews Gastroenterology &Hepatology
- 2017
- 55
Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia
- Biology, Medicine
- The Journal of pathology
- 2011
- 18
- PDF