An evolutionary perspective on FoxP2: strictly for the birds?

@article{Scharff2005AnEP,
  title={An evolutionary perspective on FoxP2: strictly for the birds?},
  author={Constance Scharff and Sebastian Haesler},
  journal={Current Opinion in Neurobiology},
  year={2005},
  volume={15},
  pages={694-703}
}

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References

SHOWING 1-10 OF 98 REFERENCES

Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction

In situ hybridization analyses for FoxP1 and FoxP2 in a songbird reveal a corticostriatal expression pattern congruent with the abnormalities in brain structures of affected KE family members, suggesting combinatorial regulation by these molecules during neural development and within vocal control structures may occur.

Molecular evolution of FOXP2, a gene involved in speech and language

It is shown that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution.

Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum

The striatum is known to be involved in the process of procedural memory, and mutation of Foxp2 results in neurological disorders of language and speech, so the striatum, particularly the striosomal system, may participate in neural information processing for language and Speech.

FoxP2 Expression in Avian Vocal Learners and Non-Learners

Most vertebrates communicate acoustically, but few, among them humans, dolphins and whales, bats, and three orders of birds, learn this trait. FOXP2 is the first gene linked to human speech and has

FoxP2 in song-learning birds and vocal-learning mammals.

While FoxP2 appears to be under strong functional constraints in mammals and birds, it is found that there is no evidence for its role during the evolution of vocal learning in nonhuman animals as in humans.

FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.

The homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species.

FOXP2 and the neuroanatomy of speech and language

The discovery of a mutation in FOXP2 in a family with a speech and language disorder has enabled neuroscientists to trace the neural expression of this gene during embryological development, track the effects ofThis gene mutation on brain structure and function, and so begin to decipher that part of the authors' neural inheritance that culminates in articulate speech.

Accelerated protein evolution and origins of human-specific features: Foxp2 as an example.

An important role that FOXP2 may have played in the origin of human speech is suggested and a strategy for identifying candidate genes underlying the emergences of human-specific features is demonstrated.

FOXP2 in focus: what can genes tell us about speech and language?

Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain

The time course and localization of Foxp2 and Foxp1 mRNA and protein expression in the developing and adult mouse using in situ hybridization and immunohistochemistry are investigated and a role for these genes in postmigratory neuronal differentiation is suggested.
...