An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases.

  title={An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases.},
  author={Dee R. Denver and Stephanie L Swenson and Michael Lynch},
  journal={Molecular biology and evolution},
  volume={20 10},
The helix-hairpin-helix (HhH) superfamily of base excision repair DNA glycosylases is composed of multiple phylogenetically diverse enzymes that are capable of excising varying spectra of oxidatively and methyl-damaged bases. Although these DNA repair glycosylases have been widely studied through genetic, biochemical, and biophysical approaches, the evolutionary relationships of different HhH homologs and the extent to which they are conserved across phylogeny remain enigmatic. We provide an… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 44 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase , AAG

  • E. Shimoni
  • Proc . Natl . Acad . Sci . USA
  • 2003

ATP - dependent DNA ligases

  • L. Pham, Y. Nghiem, C. Cruz, J. H. Miller
  • Genome Biol .
  • 2002

Genome sequence of the radioresistant bacterium Deinococcus radiodurans R 1

  • S. Fitz-Gibbon, J. H. Tai, E. C. Hyman, J. H. Miller
  • Science
  • 2000

Similar Papers

Loading similar papers…