An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases.

@article{Denver2003AnEA,
  title={An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases.},
  author={Dee R. Denver and Stephanie L Swenson and Michael Lynch},
  journal={Molecular biology and evolution},
  year={2003},
  volume={20 10},
  pages={1603-11}
}
The helix-hairpin-helix (HhH) superfamily of base excision repair DNA glycosylases is composed of multiple phylogenetically diverse enzymes that are capable of excising varying spectra of oxidatively and methyl-damaged bases. Although these DNA repair glycosylases have been widely studied through genetic, biochemical, and biophysical approaches, the evolutionary relationships of different HhH homologs and the extent to which they are conserved across phylogeny remain enigmatic. We provide an… CONTINUE READING

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