An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor.

@article{Kulisz2008AnEC,
  title={An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor.},
  author={Andre Kulisz and Hans-Georg Simon},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 5},
  pages={1553-64}
}
During cardiac development, the T-box transcription factor Tbx5 displays dynamic changes in localization from strictly nuclear to both nuclear and cytoplasmic to exclusively cytoplasmic along the actin cytoskeleton in cells coexpressing its binding protein LMP4. Although nuclear localization signals (NLSs) have been described, the mechanism by which Tbx5 exits the nucleus remained elusive. Here, we describe for Tbx5 a nuclear export signal (NES) that is recognized by the CRM1 export protein… CONTINUE READING