An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

@article{Brogiolo2001AnEC,
  title={An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control},
  author={Walter Brogiolo and Hugo Stocker and Tomoatsu Ikeya and Felix Rintelen and Rafael Fernandez and Ernst Hafen},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={213-221}
}
BACKGROUND Size regulation is fundamental in developing multicellular organisms and occurs through the control of cell number and cell size. Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin receptor substrate homolog Chico, the lipid kinase PI(3)K (Dp110), DAkt1/dPKB, and dS6K. RESULTS We demonstrate that varying the activity of the Drosophila insulin receptor homolog (DInr) during… CONTINUE READING
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