An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

@article{Matsumoto2000AnEC,
  title={An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.},
  author={M. Matsumoto and T. Saito and J. Takasaki and M. Kamohara and T. Sugimoto and M. Kobayashi and M. Tadokoro and S. Matsumoto and T. Ohishi and K. Furuichi},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={272 2},
  pages={
          576-82
        }
}
We report here a novel family of G-protein coupled receptor (GPCR) which is extraordinarily conserved among vertebrate species. This family, designated SREB (Super Conserved Receptor Expressed in Brain), consists of at least three members, termed SREB1, SREB2, and SREB3. SREB members share 52-63% amino acid identity with each other and show relatively high similarity to previously known amine amine GPCRs (approximately 25% identity). Amino acid sequence identity between human and rat… Expand
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References

SHOWING 1-10 OF 16 REFERENCES
Discovery of three novel G-protein-coupled receptor genes.
Inactivation of a Novel Neuropeptide Y/Peptide YY Receptor Gene in Primate Species*
  • Mitsuyuki Matsumoto, T. Nomura, +7 authors Tokio Yamaguchi
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1996
The family of G‐protein‐coupled receptors
G Protein-coupled Receptors
Full-length cDNA cloning and distribution of human dopamine D4 receptor.
pEF-BOS, a powerful mammalian expression vector.
...
1
2
...