An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

  title={An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.},
  author={Mitsuyuki Matsumoto and Takashi Saito and Jun Takasaki and Masazumi Kamohara and Toru Sugimoto and M. Kobayashi and Makoto Tadokoro and Shun-ichiro Matsumoto and Takahide Ohishi and Kiyoshi Furuichi},
  journal={Biochemical and biophysical research communications},
  volume={272 2},
We report here a novel family of G-protein coupled receptor (GPCR) which is extraordinarily conserved among vertebrate species. This family, designated SREB (Super Conserved Receptor Expressed in Brain), consists of at least three members, termed SREB1, SREB2, and SREB3. SREB members share 52-63% amino acid identity with each other and show relatively high similarity to previously known amine amine GPCRs (approximately 25% identity). Amino acid sequence identity between human and rat… 

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