An evidence-based review of oral magnesium supplementation in the preventive treatment of migraine
@article{Teigen2015AnER, title={An evidence-based review of oral magnesium supplementation in the preventive treatment of migraine}, author={Levi M. Teigen and Christopher J. Boes}, journal={Cephalalgia}, year={2015}, volume={35}, pages={912 - 922} }
Background Migraine is an incompletely understood, debilitating disorder that lacks a universally effective treatment. Magnesium participates in a variety of biochemical processes related to migraine pathophysiology, and a deficiency could contribute to migraine development. Methods A review of the literature from 1990 to the present on magnesium and migraine was conducted. Review The authors identified 16 studies aimed at magnesium status assessment in migraine, and four intervention trials…
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References
SHOWING 1-10 OF 83 REFERENCES
The effects of magnesium prophylaxis in migraine without aura.
- Medicine, PsychologyMagnesium research
- 2008
It is thought that magnesium is a beneficial agent in prophylaxis of migraine without aura and might work with both vascular and neurogenic mechanisms.
Nutraceuticals in the prophylaxis of pediatric migraine: Evidence-based review and recommendations
- MedicineCephalalgia : an international journal of headache
- 2014
The quality of the evidence for the use of nutraceuticals in pediatric migraine prophylaxis is poor and further research needs to be done in order to study the efficacy of nutRaceuticals for the proPHylaxis of pediatric migraine.
Prophylaxis of Migraine with Oral Magnesium: Results From A Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study
- MedicineCephalalgia : an international journal of headache
- 1996
High-dose oral magnesium appears to be effective in migraine prophylaxis and duration and intensity of attacks and the drug consumption per attack tended to decrease compared to placebo but failed to be significant.
Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED]
- Medicine, PsychologyNeurology
- 2012
OBJECTIVE
To provide updated evidence-based recommendations for the preventive treatment of migraine headache. The clinical question addressed was: Are nonsteroidal anti-inflammatory drugs (NSAIDs)…
Canadian Headache Society guideline for migraine prophylaxis.
- MedicineThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
- 2012
There is good evidence from randomized controlled trials for use of a number of different prophylactic medications in patients with migraine, and medication choice for an individual patient requires careful consideration of patient clinical features.
Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults
- Medicine, PsychologyNeurology
- 2012
Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity.
Magnesium in the Prophylaxis of Migraine—a Double-Blind, Placebo-Controlled Study
- Medicine, PsychologyCephalalgia : an international journal of headache
- 1996
The migraine prophylactic effect of 10 mmol magnesium twice-daily has been evaluated in a multicentre, prospective, randomized, double-blind, placebo-controlled study, with no benefit with magnesium compared to placebo.
Why all migraine patients should be treated with magnesium
- MedicineJournal of Neural Transmission
- 2012
Empiric treatment with at least oral magnesium is warranted in all migraine sufferers because both oral and intravenous magnesium are widely available, extremely safe, very inexpensive and for patients who are magnesium deficient can be highly effective.
Serum and erythrocyte magnesium concentrations and migraine.
- Psychology, MedicineMagnesium research
- 1992
The findings support the hypothesis of a magnesium deficit in people suffering from migraine and raise the problem of the relationship between migraine and other pathologies, including chronic magnesium deficit, latent tetany due to magnesium deficiency, mitral valve prolapse, and allergy.
Intravenous Magnesium Sulfate Rapidly Alleviates Headaches of Various Types
- MedicineHeadache
- 1996
Intravenous infusion of 1 gram of MgSO4 results in rapid relief of headache pain in patients with low serum IMg2+ levels, which may have a practical application in many types of headache patients.