An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis.

@article{SandbergWollheim1995AnEO,
  title={An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis.},
  author={Magnhild Sandberg-Wollheim and Emilio Ciusani and Andrea Salmaggi and Flemming Pociot},
  journal={Multiple sclerosis},
  year={1995},
  volume={1 3},
  pages={181-5}
}
We have analyzed the distribution of tumor necrosis factor (TNF) a and -b microsatellite alleles in HLA-DQ and -DR typed Swedish patients with multiple sclerosis (MS) (n = 122) and ethnically matched control subjects (n = 178). We found significant differences in the frequencies of TNFa and TNFb alleles between patients and controls. TNFaII was significantly associated with MS. This was also the case for the combination of TNFaII with TNFb4. However, TNFaII (alone or in combination with TNFb4… CONTINUE READING

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