An evaluation of the role of ethanol clearance rate in the differential response of long-sleep and short-sleep mice to ethanol.

@article{Phillips1984AnEO,
  title={An evaluation of the role of ethanol clearance rate in the differential response of long-sleep and short-sleep mice to ethanol.},
  author={Tamara J Phillips and David M. Gilliam and Bruce C. Dudek},
  journal={Alcohol},
  year={1984},
  volume={1 5},
  pages={373-8}
}
Ethanol (ETOH) clearance rates were determined in Long-Sleep (LS) and Short-Sleep (SS) mice, which were selectively bred for differential soporific response to ETOH. Determination of blood ethanol levels at 45 min intervals following administration of 3.8 g/kg IP indicated that SS mice clear ETOH at a faster rate. Repeatedly sampled mice of each line cleared ETOH more slowly than those where samples were taken only once. A second experiment utilized pairs of LS and SS mice matched on body… CONTINUE READING