An evaluation of the locomotor stimulating action of ethanol in rats and mice

  title={An evaluation of the locomotor stimulating action of ethanol in rats and mice},
  author={Gerald D. Frye and George R. Breese},
The locomotor activity of groups of three CD-1 female mice was increased by 1.0 and 2.0 g/kg ethanol, IP, was decreased during the first hour and increased during the second hour by 3.0 and 4.0 g/kg, and was decreased by 5.0 g/kg. The dose (2.0 g/kg) that caused the greatest increase in locomotor activity did not impair motor coordination, measured by the height of aerial righting in mice. Tests after oral administration of ethanol showed that the increase in locomotor activity of mice was not… 
Response variability of ethanol-induced locomotor activation in mice
Chronic exposure to ethanol increased the ethanol-induced locomotor activation in both EA and ENA groups, and the possibility that the lack of responsiveness of ENA mice to ethanol's acute activating effect could be due to a higher sensitivity to the depressant effect of ethanol is discussed.
Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice
The results add further support to the notion that the behavioral effects of ethanol vary with dose, time of administration and the behavioral measure taken.
Ethanol-induced locomotor stimulation in C57BL/6 mice following RO15-4513 administration
It is suggested that RO15-4513 unmasked the stimulant effects of ethanol by virtue of its ability to antagonize the depressant properties of ethanol in C57BL/6 mice.
Time course of the locomotor stimulant and depressant effects of a single low dose of ethanol in mice
Ethanol appeared to produce two distinct types of depression, in terms of increased immobility (and suppression of other behaviour) and in Terms of decreased ambulation, the latter occurring when immobilities had returned to baseline levels.
Acute Effects of Ethanol on Spontaneous Locomotor Activity in both Experimentally Diabetic and Non-diabetic Rats
It is reported that diabetes alters functions of brain neurotransmitters, presumably thereby inducing the alteration of locomotor activity in rats, and possible involvement of EtOH-induced alterations of neurotransmitter system in the brain is discussed.
Analysis of the biphasic locomotor response to ethanol in high and low responders to novelty: a study in nijmegen wistar rats
It is concluded that the mechanism underlying the ethanol-induced motor excitation differs completely from that underlying theanol-induced sedation.
Agmatine blocks ethanol-induced locomotor hyperactivity in male mice.


Alteration of ethanol-induced changes in locomotor activity by adrenergic blockers in mice
Results indicate that the SLMA-depressant effect of ETOH may be mediated by central “beta-type” receptors, that theSLMA-stimulant effect by ETOh may bemediated by central "alpha-type" receptors, and that at least part of EtoH's action may be due to dopaminergic mechanisms.
Ethanol-induced mouse strain differences in locomotor activity
Antagonism of ethanol's central stimulation in mice by small doses of catecholamine-receptor agonists
Ethanol's behavioural stimulant action in mice can be largely suppressed by apomorphine or clonidine, drugs which in the small doses used probably inhibit central catecholamine (CA) neurons.
Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis
The possibility that the inhibitory effects of the dopamine-agonists on the ethanol-induced stimulation of the serotonin synthesis and locomotor activity may be mediated by stimulation of presynaptic, inhibitory receptors is discussed.
Suppression of ethanol-induced locomotor stimulation by GABA-like drugs
Ethanol was given intraperitoneally to mice and was found to cause a marked increase in spontaneous locomotor activity, indicating a potential interaction between GABA-like drugs and alcohol in man, and may be of heuristic value in the treatment of chronic alcoholism.
Significance of acetaldehyde in ethanol-induced effects on catecholamine metabolism and motor activity in the mouse
It is concluded that Acetaldehyde is not necessary to obtain the effects of ethanol on 3H-CA-accumulation and motor activity in the mouse and the slight CA-releasing effect of ethanol and acetaldehyde is different from that of low doses of amphetamine and may possibly imply release of amines from the storage granules.
Suppression by α-methyltyrosine of ethanol-induced locomotor stimulation: Partial reversal by l-Dopa
The view that central catecholamines are involved in the stimulatory action of ethanol on locomotor activity is supported and appears to be optimal at a low dose of l-Dopa, 5–20 mg/kg, which by itself did not appear to influence the locomotorActivity.
Antagonism by nialamide of the ethanol-induced locomotor stimulation in mice
Administration of ethanol (2 g/kg, 20% w/v i.p.) to mice produced a significant increase in their locomotor activity and the possibility that this effect of nialamide is mediated by a feed-back mechanism is discussed.