An evaluation of the in vitro cytotoxicities of 50 chemicals by using an electrical current exclusion method versus the neutral red uptake and MTT assays.

@article{Lindl2005AnEO,
  title={An evaluation of the in vitro cytotoxicities of 50 chemicals by using an electrical current exclusion method versus the neutral red uptake and MTT assays.},
  author={Toni Lindl and Birgit Lewandowski and Sonya Schrey{\"o}gg and Andrea Staeudte},
  journal={Alternatives to laboratory animals : ATLA},
  year={2005},
  volume={33 6},
  pages={591-601}
}
According to the 2001 National Institutes of Health guidance document on using in vitro data to estimate in vivo starting doses for acute toxicity, the performance of the electrical current exclusion method (ECE) was studied for its suitability as an in vitro cytotoxicity test. In a comparative study, two established in vitro assays based on the quantification of metabolic processes necessary for cell proliferation or organelle integrity (the MTT/WST-8 [WST-8] assay and the neutral red uptake… CONTINUE READING
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