An evaluation of the effect of NAS-181, a new selective 5-HT1B receptor antagonist, on extracellular 5-HT levels in rat frontal cortex

@article{Groote2003AnEO,
  title={An evaluation of the effect of NAS-181, a new selective 5-HT1B receptor antagonist, on extracellular 5-HT levels in rat frontal cortex},
  author={Lotte de Groote and Andr{\'e} A. Klompmakers and Berend Olivier and Herman G. M. Westenberg},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2003},
  volume={367},
  pages={89-94}
}
In the mammalian brain 5-HT1B receptors are present as autoreceptors regulating the release of serotonin (5-HT) by inhibitory feedback. The antagonistic properties of NAS-181 ((R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methane sulfonate), a new selective antagonist for the rodent 5-HT1B receptor, were determined by using an agonist-induced decrease of extracellular 5-HT. The 5-HT1B receptor agonist CP93129 (0.030.3 μM) applied by reversed microdialysis, dose… CONTINUE READING

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