An evaluation of the early pharmacodynamic response after simultaneous initiation of warfarin and amiodarone.

@article{Edwin2010AnEO,
  title={An evaluation of the early pharmacodynamic response after simultaneous initiation of warfarin and amiodarone.},
  author={Stephanie B Edwin and Douglas L. Jennings and James S. Kalus},
  journal={Journal of clinical pharmacology},
  year={2010},
  volume={50 6},
  pages={693-8}
}
Amiodarone inhibits the metabolism of warfarin. Previous studies characterizing this drug interaction have focused on the effect of adding amiodarone to stable doses of warfarin. The objective of this study was to assess whether simultaneous initiation of warfarin and amiodarone results in early alteration of the international normalized ratio (INR) response to warfarin. Patients initiated on warfarin and amiodarone during the same hospitalization were included in the amiodarone (AMIO) group… CONTINUE READING