An evaluation of the dorset sheep as a predictive animal model for the response of glucose-6-phosphate dehydrogenase-deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl oleate ozonide.

  title={An evaluation of the dorset sheep as a predictive animal model for the response of glucose-6-phosphate dehydrogenase-deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl oleate ozonide.},
  author={Edward J. Calabrese and P S Williams and Gary S. Moore},
  journal={Ecotoxicology and environmental safety},
  volume={7 4},
10 Citations
Attempts to validate a possible predictive animal model for human erythrocyte G‐6‐PD deficiency
The results indicated that metabolites of the Pharmaceuticals, B‐naphthol, dapsone, and sulfanilamide, are oxidant, which agreed with studies on the response of human G‐6‐PD deficient erythrocytes.
Screening for potential hemolytic responses to environmental agents using a bioactivation system: Evaluation of six pesticides
The results indicated that the parent compounds of all the pesticides and the metabolites of all pesticides except diuron were not oxldant stressor agents towards G‐6‐PD deficient erythrocytes, in vitro.
Use of a bioactivation system to screen for hemolytic response to environmental agents: Evaluation of six pesticides
The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes, in vitro.
Erythrocyte defense against hydrogen peroxide: preeminent importance of catalase.
An important role for catalase in protection against H2O2-mediated damage at physiologic levels is suggested andcatalase is as at least as important as glutathione in cellular defense against H 2O2.
Methyl Oleate Ozonides in Aqueous Micelles: Formation, Stability, and Initiation of Lipid Peroxidation, And, Relative Antioxidant Efficiencies in Aqueous Micelles of Anionic and Cationic Surfactants.
Ozonation of methyl oleate has been shown for the first time to form ozonides in aqueous micelles of sodium dodecyl sulfate (SDS) and in L-a-distearoylphosphatidylcholine (DSPC) liposomes. The total
Animal models of inherited hematologic disease.
  • J. Kaneko
  • Medicine, Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 1987
Biological Models in Radiopharmaceutical Development
This work describes the design of Candidate Radiopharmaceuticals, and the selection of Biological Models, for drug development and Moral and Ethical Considerations, as well as principles and training programs for research with Animals.
Separation and spectral data of the six isomeric ozonides from methyl oleate
The assignments for the six isomeric ozonides of methyl oleate have been made by1H and13C nuclear magnetic resonance (NMR), which were consistent with the retention times observed in high-performance liquid chromatography; the assignments were confirmed by mass and infrared spectroscopy.


Effect ofin vivo ozone exposure to dorset sheep, an animal model with low levels of erythrocyte glucose-6-phosphate dehydrogenase activity
  • G. Moore, E. Calabrese, E. Schulz
  • Biology, Environmental Science
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 1984
Female Dorset sheep were exposed in vivo to ambient ozone levels and the effects of this exposure upon erythrocytes were studied, showing biochemical evidence of oxidant stress as indicated by decreases in GSH levels and ACHE and increases in MetHb.
Ozone and human blood.
Serum GSSRase activity, however, was significantly decreased while serum vitamin E, and lipid peroxidation levels were significantly increased, and alterations tend to disappear gradually, but were still detectable two weeks following exposure.
The effect of methyl linoleate hydroperoxide (MLHP), a possible toxic intermediate of ozone, on human normal and glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficient erythrocytes
The G‐ 6‐PD deficient eryth‐rocytes displayed a markedly enhanced sensitivity to MLPH induced decreases in G‐6‐PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels.
Prevention of Ozonide-Induced Heinz Bodies in human Erythrocytes by Vitamin E.
Observations suggest that the protective effects of vitamin E against ozone-produced toxicants occurs in man as well as in animals.
Ozone: a possible cause of hemolytic anemia in glucose-6-phosphate dehydrogenase deficient individuals.
A theoretical model is described that predicts that individuals with a glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis on exposure to ozone at levels reached in certain
Introductory remarks: Session on genetic factors affecting pollutant toxicity.
  • D. Gardner
  • Environmental Science
    Environmental health perspectives
  • 1979
It becomes vitally important to carefully define the population at risk, the mode of exposure, and the lowest concentration that will cause an adverse health effect, because in many instances the action of one toxic agent can be modified by exposure to other agents.
The last twenty years have seen a great increase in the use of statistical methods in various branches of science and technology. One of the obstacles to the more widespread use of these methods is