An evaluation of the dorset sheep as a predictive animal model for the response of G-6-PD deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl oleate hydroperoxide.

@article{Calabrese1983AnEO,
  title={An evaluation of the dorset sheep as a predictive animal model for the response of G-6-PD deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl oleate hydroperoxide.},
  author={Edward J. Calabrese and Gary S. Moore and P S Williams},
  journal={Veterinary and human toxicology},
  year={1983},
  volume={25 4},
  pages={
          241-6
        }
}
Erythrocytes of both G-6-PD deficient humans and Dorset sheep, an animal model with an erythrocyte G-6-PD deficiency, both responded in a dose dependent manner to the oxidant stress of MOHP as measured by decreases in G-6-PD activity, increases in METHB levels and decreases in GSH. However, the human G-6-PD deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for the GSH parameter. The results suggest a… 
5 Citations
Attempts to validate a possible predictive animal model for human erythrocyte G‐6‐PD deficiency
TLDR
The results indicated that metabolites of the Pharmaceuticals, B‐naphthol, dapsone, and sulfanilamide, are oxidant, which agreed with studies on the response of human G‐6‐PD deficient erythrocytes.
Use of a bioactivation system to screen for hemolytic response to environmental agents: Evaluation of six pesticides
TLDR
The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes, in vitro.
Screening for potential hemolytic responses to environmental agents using a bioactivation system: Evaluation of six pesticides
TLDR
The results indicated that the parent compounds of all the pesticides and the metabolites of all pesticides except diuron were not oxldant stressor agents towards G‐6‐PD deficient erythrocytes, in vitro.
Increased resistance to oxidative stress in normal and glucose-6-phosphate dehydrogenase-deficient hemolysates in the presence of enzyme substrates
TLDR
Chemiluminescence intensities in erythrocytes of normal and deficient subjects were similar in the presence or absence of glucose-6-phosphate dehydrogenase substrates, but with the addition of substrates to the incubation medium, deficient hemolysates reached maximum chemilumine intensity within a shorter period, and maximum values were higher than in normal hemysates.

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