An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes.

@article{Masubuchi1998AnEO,
  title={An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes.},
  author={Noriko Masubuchi and Albert P Li and Osamu Tatsuma Okazaki},
  journal={Chemico-biological interactions},
  year={1998},
  volume={114 1-2},
  pages={1-13}
}
Primary human hepatocytes contain a full complement of human drug-metabolizing enzymes and therefore represent a relevant experimental system for the evaluation of pharmacokinetic drug-drug interaction potential in human. In this study, the cytochrome P450 (CYP) induction potential of pantoprazole (PAN) was evaluated and compared to two other proton pump inhibitors (PPIs), omeprazole (OM) and lansoprazole (LAN). Primary human hepatocytes from three donors were studied. The hepatocytes were… CONTINUE READING