An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis.

@article{Williamson2012AnEO,
  title={An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis.},
  author={Deborah A. Williamson and Indira Basu and James Bower and Joshua T. Freeman and Gillian Henderson and Sally A. Roberts},
  journal={Diagnostic microbiology and infectious disease},
  year={2012},
  volume={74 2},
  pages={207-9}
}
Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases. 
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