An evaluation of four commercial HPLC chiral detectors: a comparison of three polarimeters and a circular dichroism detector.

  • Laila Kott, W. Brian Holzheuer, +1 author Gregory K Webster
  • Published 2007 in Journal of pharmaceutical and biomedical analysis
With increasing frequency, new drug candidates being introduced into pharmaceutical drug pipelines are chiral. Often only one enantiomer exhibits the desired biological activity and the other enantiomer may exhibit undesired side effects, thereby making chiral purity an important parameter. The introduction of chiral analysis adds additional complications… (More)