An evaluation of current cholera treatment

@article{Bhattacharya2003AnEO,
  title={An evaluation of current cholera treatment},
  author={Sujit Bhattacharya},
  journal={Expert Opinion on Pharmacotherapy},
  year={2003},
  volume={4},
  pages={141 - 146}
}
Cholera, caused by Vibrio cholerae O1 and O139, is characterised by profuse purging of watery stools, and vomiting and dehydration. The mainstay of therapy of cholera patients is rehydration with oral rehydration salt solution or intravenous Ringer’s lactate depending upon the degree of dehydration. Antibiotics such as tetracycline, doxycycline, norfloxacin, ciprofloxacin and furazolidone may be used as an adjunct to rehydration therapy for severely purging cholera patients to reduce the rate… Expand
Susceptibilidad a agentes antimicrobianos de cepas vacunales atenuadas de Vibrio cholerae
TLDR
Nine strains of V. cholerae, which included the Cuban CV638 oral vaccine candidate as well as other three strains, obtained from a strain O139 serogroup, showed that the strains could be used for decontamination of the vaccine strain in volunteers, submitted to clinical trials. Expand
Epidemiology & antibiograms of Vibrio cholerae isolates from a tertiary care hospital in Chandigarh, north India.
TLDR
The emergence of resistance amongst V. cholerae especially towards ciprofloxacin may significantly influence the control strategies in future outbreaks of cholera in north India. Expand
The burden of cholera
TLDR
Insight is given into the disease prevalence, pandemic, epidemiology, pathogenesis, disease transmission, major strategies and steps to be pursued toward controlling cholera. Expand
Vaxchora: The First FDA-Approved Cholera Vaccination in the United States.
TLDR
Travelers can now visit areas with less chance of contracting the bacterium Vibrio cholerae, which causes cholera infections, with the approval of Vaxchora, a live attenuated, single-dose, oral suspension vaccine. Expand
Vibrio Pathogenicity Island-1: The Master Determinant of Cholera Pathogenesis
TLDR
The present understanding of the different functions of VPI-1 those are associated with virulence, important for toxin production and essential for the disease development are discussed. Expand
Diarrheal Diseases in Low- and Middle-Income Countries: Incidence, Prevention and Management
TLDR
Treatment of diarrhea in children includes oral rehydration with a pre-formulated solution or with fluids that can be prepared and administered in the home, and zinc supplementation is recommended. Expand
Safety and Efficacy Review of Doxycycline
Doxycycline is a member of the tetracycline class of antibiotics and has been used clinically for more than 40 years. It is a well-tolerated drug that is bacteriostatic and acts via the inhibition ofExpand
Antibacterial Spectrum and Susceptibility of Bacterial Pathogens Causing Diarrheal Illnesses: Cross Sectional Study of Patients Visiting Health Facility in Lake Victoria Region - Kenya
TLDR
With the observed trends in this study, bacterial species have responded differently to antibiotics and it may be beneficial for clinicians to consider antibiotic susceptibility testing prior to management of patients to slow down resistance development. Expand
Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa
TLDR
These results demonstrate that final effluents from wastewater treatment plants are potential reservoirs of various antibiotics resistance genes and detection of resistance genes in Vibrio strains obtained from the wastewater final effluent suggests that these resistance determinants might be further disseminated in habitats downstream of the sewage plant, thus constituting a serious health risk to the communities reliant on the receiving waterbodies. Expand
Antimicrobial Activity of Padigalinga Chenduram against Enteric Pathogens
TLDR
Padigalinga  Chenduram was investigated for antibacterial potential against enteric pathogens like Escherichia coli, Salmonella typhi by Agar well diffusion method, implying that the herbo mineral compound may be useful as an alternative in the treatment ofEnteric pathogens. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 41 REFERENCES
Mechanism and treatment of diarrhoea due to Vibrio cholerae and Escherichia coli: roles of drugs and prostaglandins.
TLDR
CPZ, berberine, and nicotinic acid are potential antidiarrhoeal agents, tetracycline and furazolidone are effective antimicrobial agents in cholera, and glucose short-chain polymers are better sources of carbohydrates in oral rehydration solutions. Expand
Mechanism and treatment of diarrhoea due to Vibrio cholerae and Escherichia coli: roles of drugs and prostaglandins.
TLDR
It is concluded that CPZ, berberine, and nicotinic acid are potential antidiarrhoeal agents, tetracycline and furazolidone are effective antimicrobial agents in cholera, and glucose short-chain polymers are better sources of carbohydrates in oral rehydration solutions. Expand
The rational use of drugs in the treatment of acute diarrhoea.
TLDR
The key to the management of acute watery diarrhea is ORT with antibiotics playing a very minor role; however the mother should be instructed about the proper preparation of ORS and the importance of cleanliness. Expand
Clinical profile of acute diarrhoea cases infected with the new epidemic strain of Vibrio cholerae O139: designation of the disease as cholera.
TLDR
The clinical features and blood and stool biochemical parameters of V. cholerae serogroup O139 diarrhoeal patients were indistinguishable from those in typical cholera, except for 44.3% cases infected by O139 had abdominal cramps. Expand
Emergence of Fluoroquinolone-Resistant Strains of Vibrio cholerae O1 Biotype El Tor among Hospitalized Patients with Cholera in Calcutta, India
TLDR
The emergence of fluoroquinolone-resistant strains of V. cholerae O1 Biotype El Tor among hospitalized patients with cholera is reported, believed to be the first report on such high incidence of ciprofloxacin resistance among toxigenic V.Cholera O1 strains. Expand
Expanding multiple antibiotic resistance among clinical strains of Vibrio cholerae isolated from 1992–7 in Calcutta, India
TLDR
Antimicrobial susceptibilities of Vibrio cholerae strains isolated from cholera patients admitted to the Infectious Diseases Hospital, Calcutta, India for 6 years were analysed and interesting observation encountered in this study was the dissipation of some of the resistant patterns commonly found among V. Cholerae O1 and O139 strains. Expand
Epidemic of Vibrio cholerae 0139 in Calcutta.
TLDR
As one of large outbreaks of cholera-like illness in the Indian subcontinent, Calcutta and its neighbouring areas experienced an unprecedented epidemic due to a new strain of V. cholerae non-01 since January 1993, when about 180 to 300 diarrhoea patients were admitted daily at the IDH. Expand
Spread of Vibrio cholerae O139 Bengal in India.
TLDR
The extent of spread of V. cholerae O139 Bengal in India and its ability to swiftly disseminate leaves little doubt that this is the beginning of the eighth pandemic of cholera. Expand
Ciprofloxacin for the treatment of cholera: a randomized, double-blind, controlled clinical trial of a single daily dose in Peruvian adults.
TLDR
Ciprofloxacin given once a day is as effective as the standard tetracycline regimen for the treatment of cholera in adults and may represent an alternative to the standard treatment in areas where Vibrio cholerae O1 strains that are resistant to commonly used antimicrobials are prevalent. Expand
A clinical trial of oral therapy in a rural cholera-treatment center.
TLDR
It was found that 135 patients with cholera who received oral maintenance therapy required 70% less intravenous fluid than a similar group of 135 treated at the same rural treatment center in a previous epidemic. Expand
...
1
2
3
4
5
...