An evaluation of antimicrobial treatment for whipple's disease

  title={An evaluation of antimicrobial treatment for whipple's disease},
  author={Prof. Dr. Gerhard E. Feurle and Thomas A Marth},
  journal={Digestive Diseases and Sciences},
Whipple's disease is a multisystemic disorder in which almost all organ systems can be invaded by rod-shaped bacteria. Without extended antimicrobial therapy, its course is lethal. Empirically, treatment consists of tetracyclines given for one to two years. Trimethoprim-sulfamethoxazole, a compound that crosses the blood-brain barrier, has been suggested as an alternative when patients were observed with progressive cerebral involvement. There has never been a formal evaluation of the selection… CONTINUE READING