An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model.

@article{Wen2011AnEO,
  title={An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model.},
  author={Bo Wen and Matthias Karl and David G. Pendrys and David J. Shafer and Martin A Freilich and Liisa Kuhn},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2011},
  volume={97 2},
  pages={315-26}
}
The purpose of this study was three-fold: (a) to develop a new small animal model to evaluate dental implant systems that recapitulates aspects of the challenging intraoral environment, (b) screen several scaffolds for in vivo bone forming efficacy when used to deliver non-glycosylated bone morphogenetic protein-2 (BMP-2) together with a miniaturized titanium (Ti) dental implant, and (c) identify correlations between in vitro BMP-2 release rates and in vivo results. The scaffolds tested were… CONTINUE READING
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