An evaluation of 99mTc-labeled hepatobiliary agents.

  title={An evaluation of 99mTc-labeled hepatobiliary agents.},
  author={B W Wistow and Gopal Subramanian and R L Heertum and R. Wesley Henderson and George M. Gagne and Richard C. W. Hall and John G. McAfee},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={18 5},
Scintigraphic imaging of the hepatobiliary system has been significantly improved with the development of 99mTc-labeled compounds. Two of the most promising agents, pyridoxylideneglutamate and HIDA, each formed the basis for the development of a group of structural analogs. Condensation of pyridoxal with leucine and arginine (in place of glutamate) produced pyridoxylideneleucine and pyridoxylidenearginine. Since increasing the molecular weight and the lipid solubility of compounds tends to… CONTINUE READING


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