An eukaryotic-type serine/threonine protein kinase involved in the carbon source-dependent pigment biosynthesis in Amycolatopsis mediterranei U32.

@article{Yang2001AnES,
  title={An eukaryotic-type serine/threonine protein kinase involved in the carbon source-dependent pigment biosynthesis in Amycolatopsis mediterranei U32.},
  author={Lan Yang and Wan-ju Zhang and Jui-shen Chiao and G. P. Zhao and Weihua H Jiang},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={284 2},
  pages={357-62}
}
The structural gene, pkmA, was cloned and sequenced from a rifamycin SV-producing Amycolatopsis mediterranei U32 strain. The N-terminal portion of the deduced amino acid sequence of pkmA showed significant similarity to the family of serine/threonine protein kinases. It contains all the structural features which are highly conserved in protein kinases, including the Gly-X-Gly-X-X-Gly motif of ATP binding and the essential amino acids known to be important for the recognition of the correct… CONTINUE READING