An etiological role for aeroallergens and eosinophils in experimental esophagitis.

  title={An etiological role for aeroallergens and eosinophils in experimental esophagitis.},
  author={Anil Mishra and Simon P Hogan and Eric B Brandt and Marc E Rothenberg},
  journal={The Journal of clinical investigation},
  volume={107 1},
Eosinophil infiltration into the esophagus is observed in diverse diseases including gastroesophageal reflux and allergic gastroenteritis, but the processes involved are largely unknown. We now report an original model of experimental esophagitis induced by exposure of mice to respiratory allergen. Allergen-challenged mice develop marked levels of esophageal eosinophils, free eosinophil granules, and epithelial cell hyperplasia, features that mimic the human disorders. Interestingly, exposure… CONTINUE READING


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