An estrogenic effect of 5α-androstane-3β, 17β-diol on the behavioral response to stress and on CRH regulation

  title={An estrogenic effect of 5$\alpha$-androstane-3$\beta$, 17$\beta$-diol on the behavioral response to stress and on CRH regulation},
  author={Qian Huang and Hong Zhou Zhu and David F. Fischer and Jiang-Ning Zhou},
The gender difference in behavioral and hormonal response to stress is well known, but the underlying mechanism remains elusive. Arginine-vasopressin (AVP) and corticotrophin-releasing hormone (CRH) are two major regulatory peptides in the brain involved in stress regulation. Their response to stress has been shown to be modulated by sex hormones. The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol (3beta-diol), has been identified as an estrogenic hormone. It binds to estrogen… Expand
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3betaAdiol activated ER-beta1-induced transcription mediated by an ERE equivalent to that of 17beta-estradiol and provided evidence for activation of ER signaling pathways by an androgen metabolite in neuronal cells. Expand
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