An essential yeast gene encoding a homolog of ubiquitin-activating enzyme.

@article{Dohmen1995AnEY,
  title={An essential yeast gene encoding a homolog of ubiquitin-activating enzyme.},
  author={R. J{\"u}rgen Dohmen and R Stappen and John P. McGrath and H Forrov{\'a} and Jordan Kolarov and A. Goffeau and Alexander Varshavsky},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 30},
  pages={18099-109}
}
Ubiquitin (Ub) activation by the Ub-activating (E1) enzyme is the initial and essential step common to all of the known processes that involve post-translational conjugation of Ub to itself or other proteins. The "activated" Ub, linked via a thioester bond to a specific cysteine residue in one of several Ub-conjugating (E2) enzymes, which catalyze the formation of isopeptide bonds between the C-terminal glycine of Ub and lysine residues of acceptor proteins. In the yeast Saccharomyces… CONTINUE READING

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