An essential two-component signal transduction system in Mycobacterium tuberculosis.

@article{Zahrt2000AnET,
  title={An essential two-component signal transduction system in Mycobacterium tuberculosis.},
  author={Thomas C. Zahrt and Vojo Deretic},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 13},
  pages={3832-8}
}
The bacterial two-component signal transduction systems regulate adaptation processes and are likely to play a role in Mycobacterium tuberculosis physiology and pathogenesis. The previous initial characterization of an M. tuberculosis response regulator from one of these systems, mtrA-mtrB, suggested its transcriptional activation during infection of phagocytic cells. In this work, we further characterized the mtrA response regulator from M. tuberculosis H37Rv. Inactivation of mtrA on the… CONTINUE READING

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