An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus.

@article{Fischer1990AnES,
  title={An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus.},
  author={Uwe R Fischer and Reinhard L{\"u}hrmann},
  journal={Science},
  year={1990},
  volume={249 4970},
  pages={786-90}
}
The major small nuclear ribonucleoprotein particles (snRNPs) U1, U2, U4 + U6, and U5 have to be transported from the cytoplasm, where they are synthesized, to the nucleus, where they splice pre-messenger RNAs. Since the free core snRNP proteins in the cytoplasm do not enter the nucleus on their own, the nuclear location signal must either reside on the snRNA or be created as a result of snRNA-protein interaction. Here the involvement by the 5'-terminal cap of snRNA molecules in the nucleo… CONTINUE READING

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