An essential role of the transcription factor GATA-3 for the function of regulatory T cells.

@article{Wang2011AnER,
  title={An essential role of the transcription factor GATA-3 for the function of regulatory T cells.},
  author={Yunqi Wang and Maureen A Su and Yisong Y. Wan},
  journal={Immunity},
  year={2011},
  volume={35 3},
  pages={337-48}
}
Forkhead Box P3 (Foxp3)-expressing regulatory T (Treg) cells are central to maintaining self-tolerance and immune homeostasis. How Treg cell function and Foxp3 expression are regulated is an important question under intensive investigation. Here, we have demonstrated an essential role for the transcription factor GATA-3, a previously recognized Th2 cell master regulator, in controlling Treg cell function. Treg cell-specific GATA-3 deletion led to a spontaneous inflammatory disorder in mice… CONTINUE READING
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