An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

@inproceedings{Frahm2015AnER,
  title={An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence},
  author={Silke Frahm and Beatriz Antolin-Fontes and Andreas G{\"o}rlich and J Zander and Gudrun Ahnert-Hilger and Ines Iba{\~n}ez-Tallon and Sacha B. Nelson},
  booktitle={eLife},
  year={2015}
}
A great deal of interest has been focused recently on the habenula and its critical role in aversion, negative-reward and drug dependence. Using a conditional mouse model of the ACh-synthesizing enzyme choline acetyltransferase (Chat), we report that local elimination of acetylcholine (ACh) in medial habenula (MHb) neurons alters glutamate corelease and presynaptic facilitation. Electron microscopy and immuno-isolation analyses revealed colocalization of ACh and glutamate vesicular transporters… CONTINUE READING
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