An essential role in liver development for transcription factor XBP-1.

@article{Reimold2000AnER,
  title={An essential role in liver development for transcription factor XBP-1.},
  author={Andreas M. Reimold and Amit Etkin and Isabella M. Clauss and Archibald Perkins and Daniel Friend and Jie Zhang and Heidi F. Horton and Alexander Scott and Stuart H Orkin and M. St. Clare Byrne and M. J. Grusby and L. H. Glimcher},
  journal={Genes & development},
  year={2000},
  volume={14 2},
  pages={
          152-7
        }
}
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis… CONTINUE READING

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