An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing.

@article{Onji2013AnER,
  title={An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing.},
  author={Masahiro Onji and Atsuo Kanno and Shin-ichiroh Saitoh and Ryutaro Fukui and Yuji Motoi and Takuma Shibata and Fumi Matsumoto and Aayam Lamichhane and Shintaro Sato and Hiroshi Kiyono and Kazuhide Yamamoto and Kensuke Miyake},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={1949}
}
Toll-like receptor 9 (TLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. To prevent autoimmune responses, Toll-like receptor 9 is excluded from the cell surface and silenced until the N-terminal half of the ectodomain (TLR9N) is cleaved off in the endolysosome. Truncated Toll-like receptor 9 (TLR9C) senses ingested microbial DNA, although the precise role of the truncation remains controversial. Here we show that TLR9 is expressed on… CONTINUE READING
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update on Toll-like receptors

  • T. Kawai, Akira, S. The role of pattern-recognition receptors in innat immunity
  • Nat Immunol 11, 373-384
  • 2010

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