An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Abstract

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related pathology through a senescence-associated secretory phenotype (SASP), the function of which is unclear. To understand the physiological role(s) of the complex senescent phenotype, we generated a mouse… (More)
DOI: 10.1016/j.devcel.2014.11.012

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