An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.

@article{Hajjar2005AnER,
  title={An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.},
  author={Adeline M Hajjar and Heidi L Harowicz and H. Denny Liggitt and Pamela J Fink and Christopher B Wilson and Shawn J. Skerrett},
  journal={American journal of respiratory cell and molecular biology},
  year={2005},
  volume={33 5},
  pages={470-5}
}
MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expresses ligands for multiple TLRs. MyD88(-/-) (KO) mice are highly susceptible to aerosolized P. aeruginosa, failing to elicit an early inflammatory response and permitting a 3-log increase in bacterial CFU in the lungs by 24 h after infection. We hypothesized that alveolar macrophages are the first cells to recognize and kill aerosolized P… CONTINUE READING