An essential role for ectodomain shedding in mammalian development.

  title={An essential role for ectodomain shedding in mammalian development.},
  author={Jacques J. Peschon and Jennifer L. Slack and Pranitha Reddy and Kim L. Stocking and Susan Wohler Sunnarborg and David C. Lee and William E. Russell and Beverly J. Castner and Richard S Johnson and Jeffrey N. Fitzner and Rogely Waite Boyce and Nicole E. Nelson and Carl J. Kozlosky and Martin F. Wolfson and Charles T. Rauch and Douglas Pat Cerretti and Raymond J. Paxton and Carl J. March and Roy Black},
  volume={282 5392},
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule… CONTINUE READING
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