An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor.

@article{McDonald2007AnER,
  title={An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor.},
  author={Neil A McDonald and Christopher M. Henstridge and Christopher N. Connolly and Andrew J. Irving},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 4},
  pages={976-84}
}
In central neurons, the cell-surface distribution of cannabinoid receptor subtype-1 (CB(1)) is highly polarized toward axons and is associated with synaptic terminals, in which it is well-positioned to modulate neurotransmitter release. It has been suggested that high levels of constitutive activity mediate CB(1) receptor axonal targeting, leading to domain-specific endocytosis. We have investigated further the mechanisms that underlie CB(1) receptor axonal polarization in hippocampal neurons… CONTINUE READING
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CB1 receptors in hippocampal neurons

  • AM D’Antona, KH Ahn, DA Kendall
  • J Neurosci
  • 2006
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