An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization

@article{Kinkel2016AnER,
  title={An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization},
  author={Traci L. Kinkel and Smirla Ramos-Monta{\~n}ez and Jasmine M Pando and Daniel V. Tadeo and Erin N. Strom and Stephen James Libby and Ferric C. Fang},
  journal={Nature Microbiology},
  year={2016},
  volume={2}
}
Nitric oxide (NO•) is a ubiquitous molecular mediator in biology. Many signalling actions of NO• generated by mammalian NO• synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO• has not been identified previously. Here, we show that NOS of the human pathogen… CONTINUE READING

Citations

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Nitric oxide synthase: What is its potential role in the physiology of staphylococci in meat products?

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